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KMID : 0364219880310030185
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Korean Journal of Zoology
1988 Volume.31 No. 3 p.185 ~ p.190
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Relation of the Activities of Plasminogen Activator and Plasmin-like Protease with Malignant Behavior of Skin Tumor of Rats
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Kee Yun
Park Sang-Chul
Ha Doo-Bong
Chung Chin-Ha
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Abstract
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To investigate whether malignant behavior of skin tumor correlates with changes in the level of proteolytic activities in skin tumors, rats were treated with 7,12-dimethylbenzanthracene followed by photbor ester. Tumors induced upon the treatrnents exhibited more than 20-fold increase in the activity of plasminogen activator and about 3-fold of plasmin-like activity. as compared to those in treated controls. Furthermore, the former activity was raised to about 6-fold even in the preneoplastic dssues of the skin tissues. On the other hand, the proteolytic activity against casein and insulin decreased to several-fold in the tumor tissues while antitrvpsin activity remained similar in both tumor and controls. Thus, the increase in the activities of plasmInogen activator and plasminlike enzyme appears to occur as a charaderistic to skin cancer and may involve in invasion and metsstasis of the tumor.
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KEYWORD
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Rat skin tumor , Proteloysis , Metasasis
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